Prioritized genes identified by intergrative analysis and potential therapeutic drugs


Input genes

GRIN2A
ACE

Where does this data come from?

The data obtained from Dang et al. In this publication, the authors conducted serial integrative analyses, including TWAS, PWAS, SMR, colocalization, etc. Then, they ranked the genes based on the amount of evidence, and identified potential causal genes for SCZ. According to these potential causal genes, they further used eQTL and pQTL data to identify genes and proteins with potential therapeutic drugs by performing Mendelian randomization analysis. The details can be found in the original paper. If you used this data, please cite the original paper: Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia. Nature Human Behaviour [PMID: 39753749].