Schizophrenia is one of the most common and severe psychiatric disorders, with a heritability estimated to be approximately 80%. In recent years, significant progress has been made in elucidating the genetic and molecular mechanisms underlying schizophrenia. Previously, we systematically analyzed genetic data and deposited these datasets in SZDB 1.0 and SZDB 2.0. Here, we release an updated version of the comprehensive schizophrenia genetic database, SZDB3.0. In this new version, we updated GWAS summary statistics, QTL statistics (including bulk-tissue eQTL, sQTL, mQTL, and single-cell eQTL), differential gene expression data from multiple datasets, and functional genomics data. Additionally, we have incorporated brain TWAS and PWAS statistics into the database and introduced a priority gene module containing schizophrenia risk genes supported by multiple lines of evidence, along with potential gene-targeting drugs. Finally, we also integrated protein-protein interaction data from multiple datasets and obtained over 9 million pairs of non-redundant protein-protein interactors. Based on the comprehensive performance of our SZDB3.0 database, we are confident that which will significantly facilitate research on schizophrenia.

SZDB2.0 »

Cite us:
1. Wu Y, Li X, Liu J, Luo X-J, Yao Y-G. 2020. SZDB2.0 an updated comprehensive resource for schizophrenia research. Hum Genet, 139:1285-1297. [PMID: 32385526].
2. Wu Y, Yao YG, Luo XJ. 2017. SZDB: A Database for Schizophrenia Genetic Research. Schizophr Bull, 43(2):459-471. [PMID: 27451428].